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Thus, in addition to regulating glucose control, protective effects are attributed to this incretin at the insular, neural and cardiovascular level

[17] Any additional hormonal or pituitary-modulating agents should only be used with HCG under medical supervision due to the potential for complex endocrine interactions

However, the effects build progressively , meaning it takes time to see the full range of benefits

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Conclusion As the multi-hit hypothesis holds, combining the therapeutic approaches of GLP-1 agonists with resmetirom seems like a promising strategy by targeting the multifaceted pathophysiology of MASH, which may lead to improved patient outcomes